The pilot, written by Chuck Lorre and Bill Prady and directed by the great James Burrows, takes a tired old premise and turn it into something interesting. However, there are a few irritating things (other than the “sponsored by Cadillac” messages).
The two characters are Sheldon and Leonard. Granted, not everyone will unow who Sheldon Leonard is... maybe that is why it works. And since I never watched Dharma and Greg, Chuck Lorre’s tomes at the end of his shows are fresh especially when you have a TIVO -- invented by Chuck’s friend Schlomo Tivowitz.